The current coronavirus outbreak (COVID-19) has spread over the world, infecting millions of people and killing thousands of others. Despite the fact that many questions remain unanswered, our understanding of COVID-19 pathophysiology has vastly improved in many areas, including the virus's development, the role of ACE2 receptors, the type and severity of organ involvement, the importance of coagulopathy and endotheliopathy, and the role of disproportionate cytokine response. The search for a precise COVID-19 treatment has already begun. Individual vulnerability to infection, as well as inter-individual variability in clinical course, prognosis, and response to treatment, can all be elucidated using personalized medicine. Integrating personalized medicine into clinical practice has the potential to transform health care by allowing for the development of preventive and therapeutic strategies tailored to individual profiles, as well as improving outbreak detection and defining transmission patterns at a more global level.