Personalized medicine (PM) is a promising way to improve the future of personalized healthcare for all citizens, with a lot of potential in terms of disease treatment and prevention. Precision medicine is a fast-emerging health-care strategy that focuses on finding treatments and interventions that work for patients based on their genetic composition rather than their symptoms. The coming together of artificial intelligence (AI) with precision medicine has the potential to completely transform health care. Precision medicine identifies phenotypes of patients who have less-common therapeutic responses or special healthcare demands. The development of cutting-edge, innovative artificial intelligence and machine learning–based big data platforms has the potential to change medicine and allow for the rapid analysis of large amounts of data. While this presents unprecedented data storage, processing, interchange, and curation issues, it will ultimately lead to a greater understanding of biology.